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ML351

SKU: orb1306158

Description

ML351 is a potent and selective small-molecule inhibitor of 15-lipoxygenase-1 (15-LOX-1), exhibiting an IC50 of 200 nM. This compound is a valuable research tool for investigating the role of 15-LOX-1 in inflammation, atherosclerosis, and cancer in both cellular and animal models.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number847163-28-4
MW249.27
Purity97.86% (May vary between batches)
FormulaC15H11N3O
SMILESCNc1oc(nc1C#N)-c1cccc2ccccc12
TargetLipoxygenase
SolubilityDMSO:50 mg/mL (200.59 mM);10% DMSO+90% Corn Oil:2 mg/mL (8.02 mM)

Bioactivity

Target IC50
15-LOX:200 nM
In Vitro
ML351 exhibited nanomolar potency and excellent selectivity (>250-fold) versus 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2. In mouse neuronal HT22 cells, ML351 dose-dependently protected against oxidative glutamate toxicity and completely reversed the increase in 12-HETE following glutamate treatment

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

β-cell, SAH, Subarachnoid hemorrhage, T1D, oxidative stress, 15 LOX, Inhibitor, Lipoxygenase, non-obese diabetic, inhibit, LOX, ML351, ML-351, ML 351, neuronal

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  • ML351 [orb1217600]

    >98% (HPLC)

    847163-28-4

    249.27

    C15H11N3O

    1 g, 500 mg, 2 mg, 5 mg, 25 mg, 50 mg, 100 mg, 10 mg
Quality Guarantee

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Key Properties

No computed properties available.

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ML351 (orb1306158)

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% DMSO +
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% Tween 80 +
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Available Sizes

Select a size below

1 mg
$ 90.00
5 mg
$ 160.00
1 ml x 10 mM (in DMSO)
$ 170.00
10 mg
$ 220.00
25 mg
$ 420.00
50 mg
$ 610.00
100 mg
$ 840.00
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