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Moracin C

SKU: orb2900235

Description

Moracin C, a natural product, is an anti-inflammatory agent. Moracin C inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from cells.

Images & Validation

Key Properties

CAS Number69120-06-5
MW310.34
Purity>98% (HPLC)
FormulaC19H18O4
SMILESCC(C)=CCc1c(O)cc(cc1O)-c1cc2ccc(O)cc2o1
TargetROS
SolubilityIn Vitro: DMSO : 250 mg/mL (805.57 mM; Ultrasonic )

Bioactivity

In Vivo
Animal model: Mice (PK Assay). Dosage: 100 mg/kg. Administration: Oral gavage. Result: Pharmacokinetic profile of Moracin C.
In Vitro
RT-PCR Cell line: RAW 264.7 macrophages Concentration: 1, 10, 25, 50 μM. Incubation time: 2 h. Result: Inhibited LPS-induced mRNA expression of iNOS and COX-2. Western blot analysis. Cell line: RAW 264.7 macrophages Concentration: 1, 10, 25, 50 μM. Incubation time: 2 h. Result: Inhibited LPS-induced TLR4 expression and NF-κB activation. Reduced phosphorylated p38, ERK and JNK levels.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

Moracin C (orb2900235)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

500 mg
2 mg
$ 400.00
5 mg
$ 630.00
10 mg
$ 900.00
25 mg
$ 1,330.00
50 mg
$ 1,780.00
100 mg
$ 2,310.00