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Norathyriol

SKU: orb1218117

Description

Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.

Images & Validation

Key Properties

CAS Number3542-72-1
MW260.2
Purity>98% (HPLC)
FormulaC13H8O6
SMILESC1=C(C=C2C(=C1O)C(=O)C3=CC(=C(C=C3O2)O)O)O
TargetAkt
SolubilityIn Vitro: DMSO : 100 mg/mL (384.32 mM)

Bioactivity

In Vivo
Norathyriol is a natural metabolite of Mangifera in the human intestine with the oral availability and safety. Norathyriol (0.92, 1.85 and 3.7 mg/kg) dose dependently decreased the serum urate levels by 27.0, 33.6 and 37.4%, respectively. Animal model: Adult Kunming mice weighing 18-22 g. Dosage: 0.92, 1.85 and 3.7 mg/kg. Administration: Administered intragastrically; twice daily for five times. Result: The serum uric acid levels were decreased by 27.0%, 33.6% and 37.4%.
In Vitro
Norathyriol (1-25 μM) inhibits growth by inducing cell cycle arrest in JB6 P+ cells. Norathyriol inhibits JB6 cell growth by inducing G2-M arrest. Norathyriol suppresses UVB-induced phosphorylation of ERKs, AP-1 and NF-κB activation in JB6 P+ cellsCell Growth Assay WB Cell Viability Assay Cell line: Mouse skin epidermal JB6 P+ cells. Concentration: 0, 1, 10, or 25 μM. Incubation time: 24 or 72 hours. Result: Inhibited cell growth in a dose- as well as time-dependent manner but does not cause cell death. Western blot analysis. Cell line: JB6 P+ cells. Concentration: 0, 1, 10, or 25 μM. Incubation time: 2 hours. Result: Inhibited UVB-induced phosphorylation of ERKs and p90RSK.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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    3542-72-1

    260.2

    C13H8O6

    5 mg, 10 mg, 1 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO), 200 mg, 25 mg
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Norathyriol (orb1218117)

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Available Sizes

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200 mg
500 mg
5 mg
$ 510.00
10 mg
$ 740.00
25 mg
$ 1,170.00
50 mg
$ 1,590.00
100 mg
$ 2,130.00