Norathyriol

SKU: orb1297266

Description

Norathyriol is a cell-permeable, orally bioavailable small molecule that potently inhibits the protein tyrosine phosphatase PTP1B. It is utilized in research areas such as diabetes and obesity, demonstrating activity in both cellular assays and animal models of metabolic disease.

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research, Molecular Biology, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	3542-72-1
MW	260.2
Purity	99.55% (May vary between batches)
Formula	C₁₃H₈O₆
SMILES	Oc1cc(O)c2c(c1)oc1cc(O)c(O)cc1c2=O
Target	DNA/RNA Synthesis,Akt,AMPK,Glucosidase,glycosidase,PPAR
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.69 mM);DMSO:65 mg/mL (249.81 mM)

Bioactivity

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Target IC50

PPARγ:153.5 μM (IC50)|PPARα:92.8 μM (IC50)|PPARβ:102.4 μM (IC50)

In Vitro

Normal or IR L6 myotubes were incubated with Norathyriol (2.5 - 10 μM, 0.625 - 2.5 μM), mangiferin (10 - 40 μM, 2.5 - 10 μM) or rosiglitazone (20 μM) and/or 0.05 nM insulin for 24 h, respectively. The glucose consumption was assessed using the glucose oxidase method. Immunoblotting was performed to detect protein kinase B (PKB/Akt) and AMP-activated protein kinase (AMPK) phosphorylation in L6 myotubes cells. Norathyriol and mangiferin treatment alone increased the glucose consumption 61.9 and 56.3%, respectively, in L6 myotubes and made additional increasing with 0.05 nM insulin. In IR L6 myotubes, Norathyriol treatment made increasing with or without insulin, mangiferin treatment also made increasing but only when co-treated with insulin. Immunoblotting results showed that Norathyriol and mangiferin produced an increase of 1.9 - and 1.8-fold in the phosphorylation levels of the AMPK, but not in Akt

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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PPAR, Peroxisome proliferator-activated receptors, RNASynthesis, RNA Synthesis, α-glucosidase, Glucosidase, Inhibitor, Mangifera, Mangiferitin, Norathyriol, inhibit, Natural, metabolite, DNASynthesis, DNA Synthesis, AMPK, anticancer, anti-bacterial, Antioxidant, antimicrobial, anti-inflammatory, AP-1, Akt

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Compound Identifiers

PubChem CID

5281656 ↗

Key Properties

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No computed properties available.

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Norathyriol (orb1297266)

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Purity:	>98% (HPLC)
CAS Number:	3542-72-1
MW:	260.2
Formula:	C₁₃H₈O₆

Norathyriol

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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