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Orelabrutinib

SKU: orb1219759

Description

Orelabrutinib is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK). (In Vitro):With a proprietary formulation, Orelabrutinib (ICP-022) achieves high bioavailability comparing to other BTK inhibitors.(In Vivo):Upon administration, Orelabrutinib (ICP-022) binds to and inhibits the activity of BTK. This prevents both the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream survival pathways, inhibiting the growth of malignant B-cells that overexpress BTK.

Images & Validation

Key Properties

CAS Number1655504-04-3
MW427.5
Purity>98% (HPLC)
FormulaC26H25N3O3
SMILESNC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC1)C(=O)C=C
TargetBTK
SolubilityDMSO:250 mg/mL (584.80 mM; Need ultrasonic)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ICP-022

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Orelabrutinib (orb1219759)

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% DMSO +
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% Tween 80 +
%

Available Sizes

Select a size below

5 mg
$ 280.00
10 mg
$ 460.00
25 mg
$ 730.00
50 mg
$ 1,000.00
100 mg
$ 1,300.00
500 mg
$ 2,570.00