Oxyphenbutazone

SKU: orb1706855

Description

Oxyphenbutazone is the active metabolite of the anti-inflammatory drug Phenylbutazone. It exhibits antimicrobial properties and is notable for its ability to selectively eliminate non-replicating Mycobacterium tuberculosis in vitro. This compound is also associated with bone marrow suppression, making it a subject of research in infectious disease and toxicology studies.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Neuroscience

Images & Validation

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Key Properties

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CAS Number	129-20-4
MW	324.37
Purity	99.88%
Formula	C₁₉H₂₀N₂O₃
SMILES	O=C1N(C=2C=CC=CC2)N(C3=CC=C(O)C=C3)C(=O)C1CCCC
Target	COX,Antibacterial
Solubility	DMSO:80 mg/mL (246.63 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.17 mM)

Bioactivity

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In Vivo	In combination with MTX (5.0 or 2.5 mg/kg/week , intraperitoneal injection), Oxyphenbutazone (70 mg/kg/week, orally, in two divided doses, for 13 weeks of treatment) showed potential anticancer activity. Read more...
In Vitro	Oxyphenbutazone enhances the anticancer effect of methotrexate (MTX) in Hep3B cells with hepatocyte repair. In Hep3B cells, 2.5-7.5 µM Oxyphenbutazone, treated for 48 hours, exhibited significant cytotoxicity when combined with MTX (0.25-1.0 µM). Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Bacterial, COX, Oxyphenbutazone

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Compound Identifiers

PubChem CID

4641 ↗

Key Properties

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No computed properties available.

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