Oxyphenbutazone

SKU: orb2901594

Description

Oxyphenbutazone is a Phenylbutazone (HY-B0230) metabolite, with anti-inflammatory effect. Oxyphenbutazone is an orally active non-selective COX inhibitor. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis.

Images & Validation

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Key Properties

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CAS Number	129-20-4
MW	324.37
Purity	>98% (HPLC)
Formula	C₁₉H₂₀N₂O₃
SMILES	CCCCC1C(=O)N(N(C1=O)c1ccc(O)cc1)c1ccccc1
Target	COX
Solubility	In Vitro: DMSO : 100 mg/mL (308.29 mM; Ultrasonic )

Bioactivity

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In Vivo

Oxyphenbutazone (70 mg/kg/week; p.o. ; in two divided doses; for 13 weeks) exerts potential anticancer activity when co-treatment with MTX (5.0 or 2.5 mg/kg/week; i.p.). Animal model: Wistar strain albino male rats (5-6 weeks; 150-220 g). Dosage: 70 mg/kg/week (co-treatment with MTX 5.0 or 2.5 mg/kg/week). Administration: PO; once a week; in two divided doses; for 13 weeks. Result: Exerted potential anticancer activity in rats when co-treatment with MTX.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

COX

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