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Recombinant Human FcRn Heterodimer Protein
SKU: orb2994565
Description
Images & Validation
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Key Properties
−| Expression System | Human Cells |
|---|---|
| Biological Origin | Human |
| Biological Activity | BLI: Loaded Recombinant Human FcRn Heterodimer (C-6His) (Cat#orb2994565) on HIS1K Biosensor, can bind Anti-Human HER2 mAb (Human IgG1) (Cat#GMP-A062) with an affinity constant of 11.3 nM as determined in BLI assay. (Regularly tested) Loaded Recombinant Human FcRn Heterodimer (C-6His) (Cat#orb2994565) on HIS1K Biosensor, can bind Anti-Human CD137 mAb (Human IgG4) (Cat#orb2993114) with an affinity constant of 0.376 uM as determined in BLI assay. (Regularly tested) Loaded Recombinant Human FcRn Heterodimer (C-6His) (Cat#orb2994565) on HIS1K Biosensor, can bind Recombinant Human IgG1 Fc (Cat#orb2993960) with an affinity constant of 98.6 nM as determined in BLI assay. (Regularly tested) Loaded Recombinant Human FcRn Heterodimer (C-6His) (Cat#orb2994565) on HIS1K Biosensor, can bind Recombinant Human IgG1 Fc (Cat#orb2992939) with an affinity constant of 0.265 uM as determined in BLI assay. (Regularly tested) Loaded Recombinant Human FcRn Heterodimer (C-6His) (Cat#orb2994565) on HIS1K Biosensor, can bind Recombinant Human IgG2 Fc (223AA) (Cat#orb2993943) with an affinity constant of 85.7 nM as determined in BLI assay. (Regularly tested) Loaded Recombinant Human FcRn Heterodimer (C-6His) (Cat#orb2994565) on HIS1K Biosensor, can bind Recombinant Human IgG2 Fc (228AA) (Cat#orb2993938) with an affinity constant of 74.5 nM as determined in BLI assay. (Regularly tested) Loaded Recombinant Human FcRn Heterodimer (C-6His) (Cat#orb2994565) on HIS1K Biosensor, can bind Recombinant Human IgG3 Fc (Cat#orb2993894) with an affinity constant of 0.101 uM as determined in BLI assay. (Regularly tested) Loaded Recombinant Human FcRn Heterodimer (C-6His) (Cat#orb2994565) on HIS1K Biosensor, can bind Recombinant Human IgG4 Fc (228AA) (Cat#orb2993937) with an affinity constant of 0.127 uM as determined in BLI assay. (Regularly tested) Loaded Recombinant Human FcRn Heterodimer (C-6His) (Cat#orb2994565) on HIS1K Biosensor, can bind Recombinant Human IgG4 Fc (224AA) (Cat#orb2993942) with an affinity constant of 48 nM as determined in BLI assay. (Regularly tested) |
| Tag | C-6His |
| Molecular Weight | Predicted: 31.2&11.7 KDa. Observed: 37&13 KDa, reducing conditions |
| Expression Region | Ala24-Ser297&Ile21-Met119 |
| Purity | SDS-PAGE: Greater than 95% as determined by reducing SDS-PAGE.. SEC-HPLC: Greater than 95% as determined by SEC-HPLC. (QC verified) |
| Endotoxins | ＜0.1EU/μg as determined by LAL test. |
| Conjugation | Unconjugated |
Storage & Handling
−| Storage | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
|---|---|
| Form/Appearance | Lyophilized |
| Buffer/Preservatives | 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, pH 7.4. |
| Reconstitution | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Expiration Date | 6 months from date of receipt. |
| Disclaimer | For research use only |
Alternative Names
−IgG receptor FcRn; Neonatal Fc receptor; FCRN
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Recombinant Human FcRn Heterodimer Protein (orb2994565)
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