Cart summary

You have no items in your shopping cart.

Rotundine

SKU: orb1300586

Description

Rotundine (L-THP, Gindarine) is a selective dopamine D1 receptor antagonist with an IC50 of 166 nM. It is widely used in neuroscience research to study dopaminergic pathways, with applications in both in vitro binding assays and in vivo behavioral models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number483-14-7
MW355.43
Purity99.91%
FormulaC21H25NO4
SMILESO(C)C=1C=C2[C@]3(N(CC=4C(C3)=CC=C(OC)C4OC)CCC2=CC1OC)[H]
Target5-HT Receptor,Dopamine Receptor
SolubilityEthanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:55 mg/mL (154.74 mM)

Bioactivity

Target IC50
D1 receptor:166 nM|D3 receptor:3300 nM|D2 Receptor:1400 nM|5-HT1A receptor:370 nM
In Vitro
Cidofovir inhibits human cytomegalovirus (HCMV) infection in cultured cells. Cidofovir is inhibitory to CMV plaque formation even when added to the cells at 48 hr post infection with IC50 of 0.9 μg/mL for Davis and 1.6 μg/mL for AD-169 strains,respectively. Cidofovir also inhibits herpes simplex virus infection. In addition, Cidofovir blocks cell fusion induced by HSV-1 in monkey kidney cells and blocks the expression of HSV-l-specific proteins and the synthesis of viral DNA.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

5-HT1A, 5-HT Receptor, 5HT Receptor, 5HTReceptor, 5-hydroxytryptamine Receptor, (-)-Tetrahydropalmatine, Dopamine, DopamineReceptor, Dopamine Receptor, D1, D2, D3, Caseanine, Gindarine, inhibit, Inhibitor, L-Tetrahydropalmatine, Serotonin Receptor, Rotundine, Tetrahydropalmatine

Similar Products

  • Rotundine [orb1305125]

    99.97% (May vary between batches)

    10097-84-4

    355.43

    C21H25NO4

    50 mg, 1 ml x 10 mM (in DMSO), 500 mg, 100 mg, 200 mg, 1 g
  • Tetrahydropalmatine [orb1305012]

    99.95% (May vary between batches)

    2934-97-6

    355.43

    C21H25NO4

    10 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO)
  • L-(R,S)-Tetrahydropalmatine (Standard) [orb3025422]

    10097-84-4

    355.43

    C21H25NO4

    10 mg
  • Rotundine [orb1222933]

    >98% (HPLC)

    10097-84-4

    355.43

    C21H25NO4

    1 g, 500 mg, 200 mg, 100 mg, 50 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

Rotundine (orb1300586)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

50 mg
$ 80.00
100 mg
$ 90.00
500 mg
$ 140.00
1 g
$ 190.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry