Rotundine

SKU: orb1305125

Description

L-(R,S)-Tetrahydropalmatine (Rotundine) is a natural alkaloid isolated from Corydalis yanhusuo. It is widely used in pharmacological research for studying its analgesic and sedative effects, with applications in both in vitro receptor binding assays and in vivo behavioral models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

−

Key Properties

−

CAS Number	10097-84-4
MW	355.43
Purity	99.97% (May vary between batches)
Formula	C₂₁H₂₅NO₄
SMILES	COC1=C(OC)C=C2C3CC4=C(CN3CCC2=C1)C(OC)=C(OC)C=C4
Target	5-HT Receptor,Dopamine Receptor
Solubility	H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:55 mg/mL (154.74 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

−

In Vitro

Rotundine displays a higher affinity to dopamine D1 than D2 receptor with Ki of 124 nM and 388 nM, respectively, while the IC50 values are 166 nM (D1) and 1.47 μM (D2), respectively. Rotundine exhibits a weak inhibitory activity against dopamine D3 with IC50 of 3.25 μM. Rotundine also potently inhibits 5-HT1A with IC50 of 374 nM and Ki of 340 nM. In addition to the antagonism of postsynaptic dopamine receptors, inhibition of presynaptic autoreceptors by Rotundine leads to increased dopamine release, which is probably attributed to lower affinity of Rotundine for D2 receptors. Along with dopamine receptors, Rotundine can interact with a number of other receptor types, including α-1 adrenergic receptors, at which it functions as an antagonist, and γ-aminobutyric acid receptors, at which it facilitates γ-aminobutyric acid binding through positive allosteric effects.

Storage & Handling

−

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

Rotundine, TETRAHYDROPALMATINE Hydrochloride, TETRAHYDROPALMATINE HYDROCHLORIDE, 5HTReceptor, 5HT Receptor, 5-HT1A, Dopamine Receptor, DopamineReceptor, D1, D2, D3, L-Tetrahydropalmatine

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

5417 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

Rotundine (orb1305125)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

Purity:	99.95% (May vary between batches)
CAS Number:	2934-97-6
MW:	355.43
Formula:	C₂₁H₂₅NO₄

Purity:	99.91%
CAS Number:	483-14-7
MW:	355.43
Formula:	C₂₁H₂₅NO₄

Purity:	>98% (HPLC)
CAS Number:	10097-84-4
MW:	355.43
Formula:	C₂₁H₂₅NO₄

Rotundine

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

Tetrahydropalmatine [orb1305012]

L-(R,S)-Tetrahydropalmatine (Standard) [orb3025422]

Rotundine [orb1300586]

Rotundine [orb1222933]

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

Rotundine (orb1305125)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors