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Saikogenin D

SKU: orb1684250

Description

Saikogenin D is a research compound with dual anti-inflammatory mechanisms: it inhibits PGE2 production without directly suppressing COX and stimulates intracellular calcium release. It also exhibits immunomodulatory properties by differentially attenuating IL-6 production in LPS-stimulated macrophages from different mouse strains, useful for studying calcium signaling and inflammatory pathways in vitro.

Research Area

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number5573-16-0
MW472.7
Purity99.99%
FormulaC30H48O4
SMILESC[C@]12[C@@]3(C)C(=C4[C@@](CO)([C@H](O)C3)CCC(C)(C)C4)C=C[C@@]1([C@]5(C)[C@@](CC2)([C@@](CO)(C)[C@@H](O)CC5)[H])[H]
TargetPotassium Channel,Prostaglandin Receptor,Calcium Channel,IL Receptor
SolubilityDMSO:≥ 80 mg/mL

Bioactivity

In Vitro
In C6 rat glioma cells, Saikogenin D (1-20 μM) inhibited calcium ionophore A23187-induced PGE2 production in a concentration-dependent manner, with an IC50 of 3 μM. In C6 rat glioma cells, Saikogenin D (10-100 μM) increased intracellular calcium concentration ([Ca²⁺]i) in a concentration-dependent manner regardless of the presence of extracellular calcium ions, with an EC50 of 35 μM.

Storage & Handling

Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CalciumChannel, Calcium Channel, ILReceptor, IL Receptor, PGE, Prostaglandin Receptor, ProstaglandinReceptor, Saikogenin D

Similar Products

  • Saikogenin D [orb3054596]

    >98% (HPLC)

    5573-16-0

    472.7

    C30H48O4

    5 mg, 100 mg, 50 mg, 25 mg
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Saikogenin D (orb1684250)

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% DMSO +
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% Tween 80 +
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Available Sizes

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1 mg
$ 140.00
5 mg
$ 280.00
10 mg
$ 400.00
25 mg
$ 630.00
50 mg
$ 880.00
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