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Saikogenin D

SKU: orb3054596

Description

Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation of [Ca2+]i that is attributed to Ca2+ release from intracellular stores.

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Key Properties

CAS Number5573-16-0
MW472.7
Purity>98% (HPLC)
FormulaC30H48O4
TargetProstaglandin Receptor
SolubilityDMSO : ≥ 100 mg/mL (211.55 mM; )

Bioactivity

In Vitro
Saikogenin D (1-20 μM) inhibits PGE2 production induced by the Ca2+ ionophore A23187 in a concentration-dependent manner with an IC50 value of 3 μM in C6 rat glioma cells. Saikogenin D (10-100 μM) elevates [Ca2+]i in a concentration-dependent manner with a EC50 value of 35 μM in the presence or absence of extracellular Ca2+ in C6 rat glioma cells.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Saikogenin D (orb3054596)

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