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Silybin

SKU: orb2813889

Description

Silybin, a flavonoid from milk thistle, acts as a broad-spectrum inhibitor of transport proteins (P-gp, MCT8) and cytochrome P450 enzymes. It is well-tolerated and applied in research on hepatoprotection, chronic liver diseases, and cosmetic formulations for its antioxidant and anti-inflammatory properties, supported by in vitro and in vivo studies.

Research Area

Cell Biology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Silybin

Key Properties

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CAS Number802918-57-6
MW482.44
Purity98.12% (May vary between batches)
FormulaC25H22O10
SMILESC(O)C1C(OC=2C(O1)=CC=C(C2)[C@H]3OC=4C(C(=O)[C@@H]3O)=C(O)C=C(O)C4)C5=CC(OC)=C(O)C=C5
TargetApoptosis,Cytochromes P450,P-gp
Solubility10% DMSO+90% Corn Oil:2 mg/mL (4.15 mM);DMSO:20 mg/mL (41.46 mM)

Bioactivity

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In Vivo
Methods: C57BL/6J mice were fed a high-fat/high-cholesterol diet for 8 weeks and treated with Silybin (50 or 100 mg/kg per day) and sodium taurodeoxycholate (TUDCA, 50 mg/kg/day) by gavage in the last 4 weeks. Blood biochemical indices and liver lipid determination as well as liver Oil Red O staining were performed to evaluate the model and lipid-lowering effects of Silybin and TUDCA. In addition, serum and liver samples were detected by a gas chromatography-mass spectrometry (GC/MS)-based metabolomics platform. Multivariate/univariate data analysis and pathway analysis were used to study differential metabolites and metabolic pathways. Results: The mouse NAFLD model was successfully established, and Silybin and TUDCA significantly reduced serum and liver lipid accumulation. Metabolomics analysis of serum and liver showed that a high-fat/high-cholesterol diet led to abnormal metabolism of metabolites in lipid metabolism, polyol metabolism, amino acid metabolism, urea cycle, and TCA cycle. Both Silybin and TUDCA treatment reversed the metabolic disturbances induced by HFD feeding.
In Vitro
Methods: HepG2 cells were treated with Silybin (0-200 mM, 24, 48, 72 hours) and cell viability was measured by MTT assay. Results: After 72 hours of treatment, the IC50 value was 68 μM.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Silibinin

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID
3086637 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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1 ml x 10 mM (in DMSO)
$ 70.00
10 mg
$ 80.00
25 mg
$ 110.00
50 mg
$ 130.00
100 mg
$ 170.00
500 mg
$ 370.00
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