Simvastatin

SKU: orb1310385

Description

Simvastatin is an orally active HMG-CoA reductase inhibitor (Ki=0.2 nM) used in research to study cholesterol biosynthesis inhibition. It is applied in hypolipidemic, cardiovascular disease, and atherosclerosis research, utilizing both in vitro enzyme assays and in vivo animal models.

Research Area

Cell Biology, Metabolism Research

Images & Validation

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Key Properties

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CAS Number	79902-63-9
MW	418.57
Purity	99.95% (May vary between batches)
Formula	C₂₅H₃₈O₅
SMILES	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12
Target	HMG-CoA Reductase,Ferroptosis,Mitophagy,Apoptosis,Autophagy
Solubility	Ethanol:100 mg/mL (238.91 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.95 mM);DMSO:50 mg/mL (119.45 mM)

Bioactivity

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Target IC50	L6 cells:229 nM\|Hepatocyte cells:1.3 nM\|MEF cells:36.7 μM\|HEK293 cells:11 μM\|Hs 68 cells:26.4 μM\|A549 cells:16.3 μM\|HMG-CoA reductase:0.1-0.2 nM (Ki)
In Vivo	METHODS: To study in vivo activity, Simvastatin (60 mg/kg, aqueous 2% DMSO+30% PEG 400+5% Tween 80) was administered by gavage to C57BL/6J mice once daily for six weeks on a CF diet. RESULTS: Simvastatin treatment reduced serum cholesterol levels by 18%, and retinal cholesterol and lipoprotein cholesterol levels by 24% and 21%, respectively. METHODS: To assay antitumor activity in vivo, Simvastatin (5-50 mg/kg in methylcellulose) was administered to BALB/c nu/nu mice by gavage once daily for three days. Subsequently, colorectal cancer cells COLO205 were subcutaneously inoculated into the right side of the mice. RESULTS: Simvastatin inhibited tumor growth in a xenograft mouse model by inducing tumor cell apoptosis and inhibiting tumor angiogenesis. Read more...
In Vitro	METHODS: BCa cells 5637, EJ and T24 were treated with Simvastatin (0.5-40 µM) for 48 h. Cell viability was measured by MTT assay. RESULTS: Simvastatin significantly inhibited the survival of the three BCa cells in a dose-dependent manner. METHODS: Human fibroblast SAEC and four tumor cells MCF7, HepG2, NCH, NCI were treated with Simvastatin (20 µM) for 72 h. Apoptosis was detected by TUNEL. RESULTS: Simvastatin induced apoptosis in different types of human tumor cells, but not in SAEC cells. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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oral activity, MK733, MK-733, MK 733, MK0733, MK-0733, Mitophagy, MK 0733, Mitochondrial Autophagy, inhibit, Inhibitor, HepG2, HMGCoA Reductase, HMG-CoA Reductase (HMGCR), HMGCoAReductase, HMG-CoA reductase, HMGCR, Ferroptosis, Huh7, cholesterol synthesis, Autophagy, anticancer, anti-proliferation activity, Apoptosis, Simvastatin

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Compound Identifiers

PubChem CID

54454 ↗

Key Properties

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No computed properties available.

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Simvastatin (orb1310385)

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Applications:	ELISA, WB
Reactivity:	Aspergillus
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Purity:	>99%
CAS Number:	101314-97-0
MW:	459.571279525757
Formula:	C₂₅H₄₀NAO₆

Purity:	99.68% (May vary between batches)
CAS Number:	121009-77-6
MW:	436.58
Formula:	C₂₅H₄₀O₆

Purity:	>99.99% (May vary between batches)
CAS Number:	189060-13-7
MW:	645.14
Formula:	C₃₃H₄₁ClN₂O₉

Purity:	98.30% (May vary between batches)
CAS Number:	139893-43-9
MW:	453.61
Formula:	C₂₅H₄₃NO₆

Simvastatin

Description

Research Area

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Key Properties

Bioactivity

Storage & Handling

Alternative Names

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