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Tenivastatin

SKU: orb1702741

Description

Tenivastatin (Simvastatin acid) is an active metabolite of simvastatin and a potent HMG-CoA reductase inhibitor used in hyperlipidemia research. It is employed in both in vitro and in vivo studies to investigate its lipid-lowering effects and its role in modulating oxidative stress by inhibiting reactive oxygen species (ROS) production.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Images & Validation

Key Properties

CAS Number121009-77-6
MW436.58
Purity99.68% (May vary between batches)
FormulaC25H40O6
SMILES[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC(O)=O)OC(=O)C(C)(C)CC
TargetReactive Oxygen Species,HMG-CoA Reductase,ROS

Bioactivity

In Vitro
In hCM and HEK293 cells transfected with OATP3A1, treatment with Simvastatin acid (0.1, 1, 10, and 20 μM; 24 hours) resulted in a dose-dependent decrease in OATP3A1 expression, ranging from 1.5% to 90% in hCMs and OATP3A1-expressing cells, respectively.

Storage & Handling

Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

L 654969, L654969, L-654969, HMG-CoA reductase, HMGCoAReductase, HMGCoA Reductase, ROS, Simvastatin acid, Simvastatin hydroxy acid, Tenivastatin

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Key Properties

No computed properties available.

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Tenivastatin (orb1702741)

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Available Sizes

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1 mg
$ 330.00
5 mg
$ 830.00
10 mg
$ 1,020.00
25 mg
$ 1,300.00
DispatchUsually dispatched within 6-8 weeks
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