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Sinapine

SKU: orb1222581

Description

Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. Sinapine has antioxidant and radio-protective activities.

Images & Validation

Key Properties

CAS Number18696-26-9
MW310.36
Purity>98% (HPLC)
FormulaC16H24NO5+
SMILESC[N+](C)(C)CCOC(=O)C=CC1=CC(=C(C(=C1)OC)O)OC
TargetAntioxidant
SolubilityIn Vitro: DMSO : 100 mg/mL (322.21 mM)

Bioactivity

In Vivo
Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota.
In Vitro
Sinapine (6 or 60 μM; 1 h) counteracts H2O2 and antimycin A-induced mitochondrial oxidative stress in cardiomyocytes. Sinapine (10-200 μM; 24 h) inhibits the proliferation of Caco-2 cells in a dose-dependent manner, and has relatively low toxicity. Sinapine (10-200 μM; 24 h) promotes doxorubicin accumulation in Caco-2 cell by inducing P-glycoprotein (P-gp) decrease. Sinapine (10-200 μM; 24 h) significantly reduces phosphorylation of FRS2α, ERK1/2.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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5 mg
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