Sodium taurodeoxycholate hydrate

SKU: orb1218485

Description

Sodium taurodeoxycholate hydrate has been used in a study to assess the effect of submicellar concentrations of bile salts on the lipid bilayer membrane.

Images & Validation

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Key Properties

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CAS Number	207737-97-1
MW	539.7
Purity	>98% (HPLC)
Formula	C₂₆H₄₄NO₆S.Na.H₂O
SMILES	C[C@H](CCC(NCCS(=O)([O-])=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C.[H]O[H].[Na+]
Target	Others
Solubility	In Vitro: H2O : 100 mg/mL (191.68 mM)

Bioactivity

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In Vivo

Taurodeoxycholate (0.5 mg/kg; i. v. ; once) confers protection to C57BL/6N mice with sepsis, but does not protect TGR5 KO mice under sepsis. Animal model: C57BL/6N mice, Lipopolysaccharides (HY-D1056) injection model of sepsis. Dosage: 0.5 mg/kg. Administration: Intravenous injection, 30 min or 24 h after LPS injection. Result: Improved the survival rate of mice with sepsis. Decreased liver and kidney damage in septic mice. Ameliorated systemic inflammation and normalized blood pressure in septic mice.

In Vitro

The median plasma concentration of Taurodeoxycholate is 33.9 nM in healthy individuals. Taurodeoxycholate inhibits the binding of N-3H-methylscopolamine to the M3 muscarinic receptor of acetylcholine with an IC50 of 170 μM. Taurodeoxycholate (0.05-1.00 mM; 1-6 days) stimulates intestinal epithelial cell proliferation. Taurodeoxycholate (0.05-1.00 mM; 24 h) induces a significant increase in S-phase concentration and a significant decrease in G1-phase concentration of the cell cycle, increases c-myc protein and mRNA expression in IEC-6 cells. Cell Proliferation Assay Cell line: IEC-6 and caco-2 cells. Concentration: 0, 0.05, 0.50, and 1.00 mM Incubation time: 1, 2, 4 and 6 days. Result: Significantly stimulated intestinal epithelial cell proliferation in a dose-dependent manner. Cell Cycle Analysis Cell line: IEC-6 cells. Concentration: 0, 0.05, 0.50, and 1.00 mM Incubation time: 24 h. Result: Significantly increased cells in S phase and decreased cells in G1-phase. Western blot analysis. Cell line: IEC-6 cells. Concentration: 0.5 mM Incubation time: 1 and 6 days. Result: Significantly increased c-myc protein expression.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Taurodeoxycholic acid sodium salt monohydrate

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