Taurodeoxycholic acid sodium hydrate

SKU: orb1297698

Description

Sodium taurodeoxycholate monohydrate is a hydrophilic bile salt used to study bile physiology. It is applied in research on biliary lipid secretion, typically using in vivo rat models and in vitro membrane permeability assays.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry

Images & Validation

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Key Properties

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CAS Number	110026-03-4
MW	539.70
Purity	99.95% (May vary between batches)
Formula	C₂₆H₄₆NNaO₇S
SMILES	C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NCCS(=O)([O-])=O)=O)([H])[C@@]3([H])[C@@](C[C@@H]1O)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C.[Na+].O
Target	Caspase,GPCR19,Apoptosis,Endogenous Metabolite
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.41 mM);DMSO:262.5 mg/mL (486.38 mM)

Bioactivity

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In Vivo

At all infusion rates, taurohyodeoxycholic acid caused a greater (P < 0.001) secretion of biliary lecithin compared to the other bile salts. There were no significant differences in the biliary secretion of cholesterol and proteins. Electron microscopy showed the recruitment of vesicles and lamellar bodies around and within bile canaliculi. In conclusion, taurohyodeoxycholic promotes a biliary lecithin secretion greater than expected from physicochemical predictions, representing a novel secretory property with potential pharmacological relevance.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Caspase, Apoptosis, Inhibitor, inhibit, Taurohyodeoxycholic acid sodium, Taurohyodeoxycholic acid sodium salt, Taurohyodeoxycholic acid sodium salt, Taurodeoxychloic Acid sodium hydrate, Taurodeoxychloic Acid sodium hydrate, Taurodeoxychloic Acid sodium Hydrate, Taurodeoxycholic acid sodium, Taurodeoxycholic acid sodium Hydrate, Taurodeoxycholic acid sodium hydrate, Sodium taurodeoxycholate, Sodium taurodeoxycholate monohydrate, Sodium taurodeoxycholate monohydrate, Sodium taurodeoxycholate Monohydrate

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Compound Identifiers

PubChem CID

23702150 ↗

Key Properties

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No computed properties available.

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