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Soyasapogenol B

SKU: orb1217837

Description

Soyasapogenol B has anti-cancer, hypocholesterolemic, anticomplementary, hepatoprotective effects, it inhibits proliferation of cultured Hep-G2.

Images & Validation

Key Properties

CAS Number595-15-3
MW458.7
Purity>98% (HPLC)
FormulaC30H50O3
SMILESC[C@]12[C@]3(C([C@@]4([H])[C@](C)([C@@H](CC(C)(C)C4)O)CC3)=CC[C@]1([H])[C@@]5([C@@]([C@](C)([C@@H](O)CC5)CO)([H])CC2)C)C
TargetApoptosis
SolubilityDMSO:10 mM

Bioactivity

In Vivo
Animal model: Xenograft murine models. Dosage: 25 or 50 mg/kg. Administration: i.p. Result: Increased the apoptotic cell death dose-dependently. Increased the expression of cleaved caspase-3, Bax, CHOP, GRP78 and LC3BII. Decreased the expression of Bcl-2 and Ki-67. Animal model: Lipopolysaccharide-induced memory impairment in mice. Dosage: 10 mg/kg. Administration: p.o. Result: Increased LPS-suppressed BDNF expression and inhibited NF-κB activation and TNF-α expression.
In Vitro
Cell Viability Assay Cell line: HCT116, SW480. Concentration: 5, 10, 20 μM. Incubation time: 24, 48 h. Result: Decreased the viability of tumor cells. Western blot analysis. Cell line: HCT116, SW480. Concentration: 10, 20 μM. Incubation time: 48 h. Result: Increased the level of caspase-3 and PARP. Decreased the expression of Bcl-2 and increased the expression of Bax. Increased the expression of LC3-II/LC3-I, Beclin 1 and Atg5, decreased the expression of p62.Apoptosis Analysis Cell line: HCT116, SW480. Concentration: 10, 20 μM. Incubation time: 48 h. Result: Increased the number of TUNEL positive cells. Increased the apoptotic percentage in HCT116 cells by more than 4 folds and 9 folds respectively, elevated to over 10% and 20% in SW480 cells.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Soyasapogenol B (orb1217837)

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% DMSO +
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% Tween 80 +
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200 mg
500 mg
5 mg
$ 270.00
10 mg
$ 410.00
25 mg
$ 720.00
50 mg
$ 1,020.00
100 mg
$ 1,370.00