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Soyasapogenol B

SKU: orb1297205

Description

Soyasapogenol B is a bioactive triterpenoid with demonstrated anti-cancer and hepatoprotective properties, including the inhibition of Hep-G2 cell proliferation in vitro. Research indicates it also exhibits hypocholesterolemic and anticomplementary activities, supporting its investigation in oncology, hepatology, and metabolic disease studies.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number595-15-3
MW458.72
Purity99.81%
FormulaC30H50O3
SMILES[H][C@@]12CC(C)(C)C[C@@H](O)[C@]1(C)CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)CC[C@H](O)[C@](C)(CO)[C@]3([H])CC[C@@]12C
TargetAutophagy,Apoptosis
SolubilityDMSO:50 mg/mL (109 mM);10% DMSO+90% Corn Oil:2 mg/mL (4.36 mM)

Bioactivity

In Vitro
Glycyrrhizin showed significant dose-dependent protective effects against the cytotoxicity of t-BuOOH. Among Soyasapogenol B and its glucuronides, the monoglucuronide showed the most potent hepatoprotective activity, followed by Soyasapogenol B itself. Soyasaponin III was weakly protective, while soyasaponin I increased the toxicity of t-BuOOH. Among sophoradiol and its glucuronides, sophoradiol itself showed the most potent hepatoprotective activity, which was equal to glycyrrhizin, while the monoglucuronide and kaikasaponin III showed an increase in cytotoxicity. These results were considerably different from those reported previously on the protective effects of these compounds using primary cultures of immunologically injured rat liver cells

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PKC, Soyasapogenol B, inhibit, Inhibitor, Apoptosis, Autophagy

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Key Properties

No computed properties available.

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Soyasapogenol B (orb1297205)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 140.00
5 mg
$ 140.00
10 mg
$ 190.00
25 mg
$ 300.00
50 mg
$ 400.00
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