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STAT5-IN-1

SKU: orb1303053

Description

STAT5-IN-1 is a cell-permeable small molecule that inhibits STAT5 activity by targeting its SH2 domain. This inhibitor is utilized in research areas such as oncology and immunology for in vitro studies of cancers and hematological disorders where STAT5 signaling is implicated.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number285986-31-4
MW293.28
Purity99.44%
FormulaC16H11N3O3
SMILESO=C(N\N=C\c1coc2ccccc2c1=O)c1cccnc1
TargetSTAT
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.82 mM);DMSO:50 mg/mL (170.49 mM)

Bioactivity

Target IC50
STAT5:47 μM
In Vitro
The chemical compound STAT5-IN-1 serves as an inhibitor of Signal Transducer and Activator of Transcription 5 (STAT5), a protein crucial for cell growth and differentiation. By attaching to the SH2 domain of STAT5, it selectively impedes its activity. While it also affects STAT3, STAT1, and the Lck tyrosine kinase, this inhibition is significantly less pronounced (IC50 > 500 μM). Additionally, STAT5-IN-1 effectively prevents the interaction between STAT5 and DNA within K562 nuclear extracts. Notably, modifying the chromone ring's C6 hydrogen to an ethyl group in STAT5-IN-1 does not diminish its efficacy against STAT5β; however, it eradicates its selectivity towards other STAT family members.

Storage & Handling

Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, inhibit, STAT5 IN 1, STAT5 Inhibitor, STAT5IN1, STAT-5-IN-1, STAT5-IN-1, STAT5β, STAT

Similar Products

  • STAT5-IN-1 [orb1225431]

    >98% (HPLC)

    285986-31-4

    293.28

    C16H11N3O3

    10 mg, 25 mg, 50 mg, 100 mg, 1 g, 500 mg, 200 mg, 5 mg
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Key Properties

No computed properties available.

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STAT5-IN-1 (orb1303053)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 90.00
5 mg
$ 90.00
10 mg
$ 130.00
25 mg
$ 230.00
50 mg
$ 370.00
100 mg
$ 590.00
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