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SU3327

SKU: orb1309054

Description

Halicin (SU3327) is a substrate-competitive and selective JNK inhibitor with an IC50 of 0.7 µM. This compound is a valuable research tool for investigating JNK signaling pathways in cellular models and has been utilized in studies exploring inflammation, apoptosis, and metabolic diseases.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number40045-50-9
MW261.3
Purity98.39%
FormulaC5H3N5O2S3
SMILESNc1nnc(Sc2ncc(s2)[N+]([O-])=O)s1
TargetJNK
SolubilityDMSO:62.5 mg/mL (239.19 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (9.57 mM)

Bioactivity

Target IC50
JNK:0.7 μM |JNK-JIP:239 nM
In Vivo
In male BKS.Cg-+Leprdb/+Leprdb/OlaHsd db/db mice, SU3327 (25 mg/kg; intraperitoneal injection; ) treatment possesses the ability to restore insulin sensitivity in mice models of diabetes. SU3327 has favorable microsomal and plasma stability (T1/2 = 27 min).
In Vitro
TNF-α stimulated phosphorylation of c-Jun in HeLa cells inhibited by SU3327 with EC50 of 6.23 μM. SU3327 (25 nM) pretreatment of human-derived cerebral microvascular endothelial cells (hCMEC/D3) effectively reduces LPS-induced polymorphonuclear leukocytes (PMN) rolling/adhesion to hCMEC/D3, prevents activation of AP-1, and significantly reduces expression of VCAM-1.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

protein-protein, SU3327, SU-3327, SU 3327, substrate-competitive, p38α, PPI, Thiadiazole, TNF-α, phosphorylation, JIP, JNK, JNK-JIP interactions, inhibit, halicin, insulin, Inhibitor

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  • SU3327 [orb1218065]

    >98% (HPLC)

    40045-50-9

    261.3

    C5H3N5O2S3

    1 g, 500 mg, 200 mg, 2 mg, 25 mg, 5 mg, 10 mg, 100 mg, 50 mg
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Key Properties

No computed properties available.

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Protocol Information

SU3327 (orb1309054)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 80.00
5 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 130.00
10 mg
$ 140.00
25 mg
$ 230.00
50 mg
$ 370.00
100 mg
$ 540.00
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