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SuperKillerTRAIL, Soluble Recombinant Protein
SKU: orb1230076
Description
Research Area
Cancer Biology, Cell Biology, Immunology & Inflammation, Signal Transduction
Images & Validation
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| Application Notes |
|---|
Key Properties
−| Source | E. coli |
|---|---|
| Biological Activity | Induces apoptosis at concentrations of >1ng/ml. Note: Does not require a cross-linking enhancer for its potent biological activity. Shows superior activity on human cell lines that require extensive cross-linking of TRAIL-Rs for killing (e.g. Jurkat). |
| Target | TNFSF10 |
| Tag | His Tag |
| Protein Sequence | The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide. The active multimeric conformation is stabilized by an inserted mutation allowing an additional CC-bridge. |
| Purity | >98% (SDS-PAGE). Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza). |
Storage & Handling
−| Storage | Once thawed it is recommended to prepare appropriate aliquots and to store them at -80°C. |
|---|---|
| Form/Appearance | Liquid |
| Buffer/Preservatives | In 20mM HEPES, pH 7.4, 150mM NaCl, 0.005% Tween 20, 1% sucrose, 1mM DTT. |
| Concentration | 0.5 mg/ml |
| Dry Ice Shipping | Please note: This product requires shipment on dry ice. A dry ice surcharge will apply. |
| Disclaimer | For research use only |
Alternative Names
−TRAIL, Apo-2L, TNFSF10, CD253
Similar Products
−SuperKillerTRAIL, Soluble Recombinant Protein [orb1230075]
>95% (SDS-PAGE). Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza).
E. coli
20 μg
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SuperKillerTRAIL, Soluble Recombinant Protein (orb1230076)
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