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Suramin

SKU: orb1982121

Description

Suramin is a multifunctional research compound that acts as a dual inhibitor of SARS-CoV-2 RdRp and host PTPases. It is utilized in antiviral, anticancer, and antiparasitic studies, with applications in both in vitro enzymatic assays and in vivo angiogenesis research models.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number145-63-1
MW1297.28
Purity99.80% (May vary between batches)
FormulaC51H40N6O23S6
SMILESO=C(NC1=CC=CC(=C1)C(=O)NC2=CC(=CC=C2C)C(=O)NC3=CC=C(C4=CC(=CC(=C34)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)NC5=CC=CC(=C5)C(=O)NC6=CC(=CC=C6C)C(=O)NC7=CC=C(C8=CC(=CC(=C78)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O
TargetTopoisomerase,Reverse Transcriptase,Parasite,DNA/RNA Synthesis,SARS-CoV,Apoptosis,Phosphatase,Sirtuin

Bioactivity

Target IC50
SIRT2:1.15 μM|SIRT5:22 μM|SIRT1:297 nM|Topo II:5 μM
In Vivo
Rats were intraperitoneally injected with 50 mg/kg Suramin once a week for 4 weeks, and the results showed that Suramin could slightly promote rat adipogenesis in vivo.
In Vitro
Low concentrations of 35 μM (50 μg/mL) and 70 μM (100 μg/mL) Suramin were not cytotoxic to prefascial adipocytes. However, high concentrations of 105 μM (150 μg/mL) and 140 μM (200 μg/mL) showed cytotoxic effects by reducing cell viability. Suramin (0-140 μM) stimulated and promoted lipogenic differentiation of FSCs in a time - and dose-dependent manner. Suramin activates Nrf2 and correspondingly inhibits the activated B cell (NF-κB) nuclear factor kappa light chain enhancer and mitogen-activated protein kinase (MAPK) pathway, thereby reducing IL-1β-stimulated chondrocyte inflammation and ECM degeneration. Suramin repolarizes M1 macrophages to M2 phenotype, further reducing apoptosis of chondrocytes.

Storage & Handling

Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Suramin (orb1982121)

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1 mg
$ 140.00
5 mg
$ 250.00
10 mg
$ 360.00
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