Cart summary

You have no items in your shopping cart.

Suramin

SKU: orb1982121

Description

Suramin is a multifunctional research compound that acts as a dual inhibitor of SARS-CoV-2 RdRp and host PTPases. It is utilized in antiviral, anticancer, and antiparasitic studies, with applications in both in vitro enzymatic assays and in vivo angiogenesis research models.

Research Area

Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Metabolism Research, Molecular Biology

Images & Validation

Key Properties

CAS Number145-63-1
MW1297.28
Purity99.80%
FormulaC51H40N6O23S6
SMILESO=C(NC1=CC=CC(=C1)C(=O)NC2=CC(=CC=C2C)C(=O)NC3=CC=C(C4=CC(=CC(=C34)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)NC5=CC=CC(=C5)C(=O)NC6=CC(=CC=C6C)C(=O)NC7=CC=C(C8=CC(=CC(=C78)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O
TargetTopoisomerase,Reverse Transcriptase,Parasite,DNA/RNA Synthesis,SARS-CoV,Apoptosis,Phosphatase,Sirtuin

Bioactivity

Target IC50
SIRT2:1.15 μM|SIRT5:22 μM|SIRT1:297 nM|Topo II:5 μM
In Vivo
Rats were intraperitoneally injected with 50 mg/kg Suramin once a week for 4 weeks, and the results showed that Suramin could slightly promote rat adipogenesis in vivo.
In Vitro
Low concentrations of 35 μM (50 μg/mL) and 70 μM (100 μg/mL) Suramin were not cytotoxic to prefascial adipocytes. However, high concentrations of 105 μM (150 μg/mL) and 140 μM (200 μg/mL) showed cytotoxic effects by reducing cell viability. Suramin (0-140 μM) stimulated and promoted lipogenic differentiation of FSCs in a time - and dose-dependent manner. Suramin activates Nrf2 and correspondingly inhibits the activated B cell (NF-κB) nuclear factor kappa light chain enhancer and mitogen-activated protein kinase (MAPK) pathway, thereby reducing IL-1β-stimulated chondrocyte inflammation and ECM degeneration. Suramin repolarizes M1 macrophages to M2 phenotype, further reducing apoptosis of chondrocytes.

Storage & Handling

Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Similar Products

  • Suramin Sodium Salt [orb1306282]

    99.33%

    129-46-4

    1429.15

    C51H34N6Na6O23S6

    25 mg, 5 mg, 10 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO)
  • NF864 [orb1701876]

    69606-09-3

    2113.5

    C57H28N6Na12O41S12

    25 mg
  • Suramin sodium salt [orb1226602]

    >98% (HPLC)

    129-46-4

    1429.2

    C51H34N6Na6O23S6

    500 mg, 200 mg, 5 mg, 10 mg, 50 mg, 100 mg, 25 mg, 1 g
  • Suramin [orb2655902]

    >98% (HPLC)

    145-63-1

    1297.3

    C51H40N6O23S6

Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

Suramin (orb1982121)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 140.00
5 mg
$ 250.00
10 mg
$ 360.00
DispatchUsually dispatched within 5-10 working days
Bulk Enquiry