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toralactone

SKU: orb1218046

Description

Toralactone is a natural product isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism.

Images & Validation

Key Properties

CAS Number41743-74-2
MW272.25
Purity>98% (HPLC)
FormulaC15H12O5
SMILESO=C1C2=C(O)C3=C(O)C=C(OC)C=C3C=C2C=C(C)O1
TargetKeap1-Nrf2
SolubilityIn Vitro: DMSO : 2.5 mg/mL (9.18 mM)

Bioactivity

In Vitro
Toralactone sensitize resistant MCF-7adr cell line to paclitaxel via inhibiting P-glycoprotein efflux activity.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information