Cart summary

You have no items in your shopping cart.

Tozadenant

SKU: orb1223797

Description

A potent, selective adenosine 2A receptor (A2A/NR2B) antagonist with Ki of 11.5 nM.Parkinson's Disease Phase 3 Discontinued(In Vivo):18F-MNI-444 regional uptake is consistent with A2A receptor distribution in the brain. Selectivity is demonstrated by dose-dependent blocking by tozadenant (1.5, 10.5 mg/kg) and preladenant.

Images & Validation

Key Properties

CAS Number870070-55-6
MW406.4991
Purity>98% (HPLC)
FormulaC19H26N4O4S
SMILESO=C(N1CCC(C)(O)CC1)NC2=NC3=C(OC)C=CC(N4CCOCC4)=C3S2
TargetAdenosine Receptor
Solubility10 mM in DMSO

Bioactivity

In Vivo
18F-MNI-444 regional uptake is consistent with A2A receptor distribution in the brain. Selectivity is demonstrated by dose-dependent blocking by tozadenant (1.5, 10.5 mg/kg) and preladenant.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SYN-115 | SYN115 | SYN 115

Similar Products

  • Tozadenant [orb1299923]

    98.00% (May vary between batches)

    870070-55-6

    406.5

    C19H26N4O4S

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO), 200 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

Tozadenant (orb1223797)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 100.00
5 mg
$ 150.00
10 mg
$ 220.00
25 mg
$ 380.00
50 mg
$ 640.00
100 mg
$ 910.00
500 mg
$ 1,920.00