Tozadenant

SKU: orb1299923

Description

Tozadenant (SYN115) is a potent and selective adenosine A2A receptor antagonist, exhibiting high affinity for both human (Ki=11.5 nM) and rhesus (Ki=6 nM) receptors. It has been utilized in preclinical research, including in vitro binding assays and in vivo models, to investigate its potential in neuroscience and Parkinson's disease studies.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

−

Key Properties

−

CAS Number	870070-55-6
MW	406.5
Purity	98.00% (May vary between batches)
Formula	C₁₉H₂₆N₄O₄S
SMILES	COc1ccc(N2CCOCC2)c2sc(NC(=O)N3CCC(C)(O)CC3)nc12
Target	Adenosine Receptor
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.92 mM);DMSO:50 mg/mL (123 mM)

Bioactivity

−

Target IC50	A2A receptor (rhesus):6 nM(Ki)\|A2A receptor (human):11.5 nM(Ki)
In Vivo	When compared to the drugs tested alone, Radiprodil and Tozadenant combination led to a significant increase of motor activity and an improvement of motor disability in MPTP-treated marmosets. In addition, the motor restoration brought about by the combination was almost completely devoid of dyskinesia Read more...
Animal Research	Before initiating the Radiprodil & Tozadenant combination experiment, 14 primates were challenged with a dose of 8 mg/kg (po) of L-Dopa and behaviour was recorded for 5 hours. This "Pre-L-Dopa-test" was used to select the 12 subjects required for the study. Their response to the L-Dopa challenge was subsequently used as a comparator to the ensuing response to the different drug treatments and combinations. The effects of the drugs alone or in combination were assessed after acute oral gavage.This experiment investigated the effects on motor deficits of Radiprodil plus Tozadenant twice daily at an interval of 5 hrs according to a modified Latin square design in n = 12 MPTP-treated marmosets. At the time of the second drugs administration a novel object (cotton reel, table tennis ball) was placed into the cage. The four different treatments were (1) Tozadenant (150 mg/kg) plus Radiprodil (2.0 mg/kg), (2) Tozadenant (150 mg/kg) plus vehicle, (3) Radiprodil (2.0 mg/kg) plus vehicle, (4) vehicle. Read more...

Storage & Handling

−

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

Tozadenant, SYN 115, SYN115, SYN-115, P1 receptor, AdenosineReceptor, Adenosine Receptor, A2A, inhibit, Inhibitor

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

11618368 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

Tozadenant (orb1299923)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

Purity:	>98% (HPLC)
CAS Number:	870070-55-6
MW:	406.4991
Formula:	C₁₉H₂₆N₄O₄S

Tozadenant

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

Tozadenant [orb1223797]

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

Tozadenant (orb1299923)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors