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VER-49009

SKU: orb1304188

Description

VER-49009 (CCT 129397) is a highly potent small molecule inhibitor of Hsp90, exhibiting an IC50 of 25 nM and a Kd of 78 nM. It is a valuable research tool for studying oncogenic client protein degradation and has demonstrated antitumor activity in both cellular assays and in vivo xenograft models.

Research Area

Metabolism Research, Signal Transduction

Images & Validation

Key Properties

CAS Number558640-51-0
MW387.82
Purity99.99%
FormulaC19H18ClN3O4
SMILESCCNC(=O)c1n[nH]c(c1-c1ccc(OC)cc1)-c1cc(Cl)c(O)cc1O
TargetHSP
SolubilityDMSO:100 mg/mL (257.85 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.31 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

Target IC50
HSP90:25 nM|HSP90:78 nM(kd)
In Vivo
Treatmented with VER-49009 results in clear depletion of ERBB2 at 3 and 8 h following the final dose, with client protein levels returning to normal by 24 h, in the athymic mice bearing well-established OVCAR3 human ovarian ascites tumors.
In Vitro
VER-49009 inhibited the proliferation of hepatic stellate cell line CFSC cells, and both of them induced G2 phase arrest in CFSC cells.
Cell Research
Antiproliferative effects are measured using the sulforhodamine B assay. HUVEC sensitivity is determined by an alkaline phosphatase method. (Only for Reference)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CCT 129397, CCT129397, CCT-129397, Heat shock proteins, Hsp90, HSP, Inhibitor, inhibit, VER49009, VER-49009, VER 49009

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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

VER-49009 (orb1304188)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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2 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 90.00
5 mg
$ 100.00
10 mg
$ 140.00
25 mg
$ 210.00
50 mg
$ 320.00
100 mg
$ 420.00
200 mg
$ 570.00
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