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VER49009

SKU: orb1305850

Description

VER49009 (CCT0129397) is a potent small molecule HSP90 inhibitor with an IC50 of 25 nM and a Kd of 78 nM. It is a valuable research tool for studying HSP90's role in oncology and neurodegenerative diseases in both cellular and animal models.

Research Area

Metabolism Research, Signal Transduction

Images & Validation

Key Properties

CAS Number940289-57-6
MW387.82
Purity100.00%
FormulaC19H18ClN3O4
SMILESc1(c(cc(c(c1)c1c(c([nH]n1)C(=O)NCC)c1ccc(cc1)OC)O)O)Cl
TargetHSP
SolubilityDMSO:71 mg/mL (183.07 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

Target IC50
HSP90:25 nM
In Vivo
VER-49009 can induce the dissociation of HSP72 and HSP27 from their binding proteins, leading to cell cycle arrest. In recombinant yeast Hsp90 protein (IC50 = 167 nM), VER-49009 inhibits the endogenous ATPase activity. During the treatment of liver fibrosis, VER-49009 induces the accumulation of hepatic stellate cells (CFSC) in the G2 phase, inhibiting cell growth.
In Vitro
In the human ovarian tumor model, intraperitoneal injection of VER-49009 (4 mg/kg) can induce the dissociation of HSP90 and ERBB2. In athymic mice, intravenous injection of VER-49009 (20 mg/kg) demonstrates efficacy.
Cell Research
Antiproliferative effects are measured using the sulforhodamine B assay. HUVEC sensitivity is determined by an alkaline phosphatase method. (Only for Reference)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CCT 0129397, CCT0129397, CCT-0129397, HSP90β, VER 49009, VER49009, VER-49009

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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

VER49009 (orb1305850)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 100.00
2 mg
$ 120.00
1 ml x 10 mM (in DMSO)
$ 140.00
5 mg
$ 160.00
10 mg
$ 220.00
25 mg
$ 340.00
50 mg
$ 540.00
100 mg
$ 720.00
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