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WR-99210

SKU: orb1307605

Description

WR99210 hydrochloride is a subnanomolar inhibitor of Plasmodium falciparum dihydrofolate reductase (pfDHFR), effective against wild-type and multidrug-resistant mutant strains. This compound is a critical research tool for studying antimalarial drug resistance mechanisms and for conducting both in vitro enzyme assays and in vivo efficacy studies in malaria models.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology

Images & Validation

Key Properties

CAS Number30711-93-4
MW431.14
Purity99.96% (May vary between batches)
FormulaC14H19Cl4N5O2
SMILESNC1=NC(N)=NC(C)(C)N1OCCCOC2=CC(Cl)=C(Cl)C=C2Cl.[H]Cl
TargetOthers,Parasite,DHFR
SolubilityDMSO:55 mg/mL (127.57 mM)

Bioactivity

In Vivo
QR992210 is more active as well as less toxic than proguanil when administered orally to mice infected with P. berghei. When administered orally to Aotus monkeys infected with multidrug-resistant P. falciparum, PS-15 was more active than either proguanil or WR99210.
In Vitro
When tested in vitro against drug-resistant clones of P. falciparum, PS-15 was more active than proguanil, and the putative metabolite, WR99210, was more active than the proguanil metabolite cycloguanil.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

pfDHFR, WR 99210, WR99210, WR99210 hydrochloride(47326-86-3 free base), 6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Protocol Information

WR-99210 (orb1307605)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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1 mg
$ 100.00
5 mg
$ 190.00
1 ml x 10 mM (in DMSO)
$ 210.00
10 mg
$ 290.00
25 mg
$ 460.00
50 mg
$ 630.00
100 mg
$ 840.00
200 mg
$ 1,100.00
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