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WR99210

SKU: orb1706465

Description

WR99210, also known as BRL 6231 free base, is an orally bioavailable dihydrofolate reductase (DHFR) inhibitor with antiparasitic properties. It is utilized in research, particularly in combination with dapsone, for investigating Mycobacterium avium complex (MAC) infections in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology

Images & Validation

Key Properties

CAS Number47326-86-3
MW394.68
Purity98.80% (May vary between batches)
FormulaC14H18Cl3N5O2
SMILESClC=1C=C(Cl)C(OCCCON2C(=NC(=NC2(C)C)N)N)=CC1Cl
TargetDHFR,Parasite
SolubilityDMSO:2 mg/mL (5.07 mM)

Bioactivity

Target IC50
DHFR:<0.075 nM
In Vivo
In a mouse model, WR99210 (1.25 mg/kg; intraperitoneal injection; once daily for 5 consecutive days) exhibited a significant inhibitory effect on T. gondii tachyzoites.
In Vitro
WR99210 (0-100 nM; 92 h) showed significant inhibition of tachyzoites of T. gondii in tissue culture. WR99210 (0-100 nM; 92 h) shows low cytotoxicity to human foreskin fibroblasts.

Storage & Handling

Storagekeep away from moisture | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Parasite, Antifolate, Bacterial, BRL 6231 free base, DHFR, WR 99210, WR99210, WR-99210

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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WR99210 (orb1706465)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 100.00
5 mg
$ 190.00
10 mg
$ 270.00
25 mg
$ 500.00
50 mg
$ 780.00
100 mg
$ 1,030.00
500 mg
$ 2,020.00
DispatchUsually dispatched within 5-10 working days
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