Cart summary

You have no items in your shopping cart.

WR99210

SKU: orb1218005

Description

WR99210 is effective against the most pyrimethamine-resistant Plasmodium falciparum strains. WR99210 is an effective inhibitor of dihydrofolate reductase (IC50:<0.075 nM).

Images & Validation

Key Properties

CAS Number47326-86-3
MW394.68
Purity>98% (HPLC)
FormulaC14H18Cl3N5O2
SMILESCC1(N=C(N=C(N1OCCCOC2=C(C=C(C(Cl)=C2)Cl)Cl)N)N)C
TargetDHFR
SolubilityDMSO : 5 mg/mL (12.67 mM; Need ultrasonic)

Bioactivity

In Vivo
WR99210 (1.25 mg/kg; i.p.; single daily for 5 days) is highly effective against T. gondii tachyzoites in a mouse model. Animal model: Male mice (T. gondii-infected). Dosage: 1.25 mg/kg. Administration: Intraperitoneal injection; single daily for 5 days. Result: Exhibited intraperitoneal parasite numbers were 2 logs less in mice on the day 5.
In Vitro
WR99210 (0-100 nM; 92 h) is highly effective against T. gondii tachyzoites in tissue culture. WR99210 (0-100 nM; 92 h) shows low cytotoxicity to human foreskin fibroblasts. Cell Viability Assay Cell line: Human foreskin fibroblasts (T. gondii-infected) Concentration: 0-100 nM. Incubation time: 92 h. Result: Showed marked inhibition of T. gondii, with an IC50 value of approximately 50 nM. Cell Cytotoxicity Assay Cell line: Human foreskin fibroblasts. Concentration: 0-100 nM. Incubation time: 92 h. Result: Lacked of toxicity for fibroblasts.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Similar Products

  • WR99210 [orb1706465]

    98.80% (May vary between batches)

    47326-86-3

    394.68

    C14H18Cl3N5O2

    5 mg, 50 mg, 100 mg, 1 mg, 10 mg, 500 mg, 25 mg
  • WR-99210 [orb1307605]

    99.96% (May vary between batches)

    30711-93-4

    431.14

    C14H19Cl4N5O2

    1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 1 ml x 10 mM (in DMSO)
  • WR-99210 [orb1218187]

    >98% (HPLC)

    30711-93-4

    431.14

    C14H19Cl4N5O2

    500 mg, 5 mg, 50 mg, 100 mg, 10 mg, 25 mg, 1 g
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

WR99210 (orb1218005)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

200 mg
500 mg
50 mg
$ 980.00
100 mg
$ 1,450.00