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Yadanzigan

SKU: orb2944186

Description

Yadanzigan (YDZG) is a natural NLRP3 inhibitor derived from Brucea javanica. It suppresses the NF-κB pathway and mitochondrial ROS while upregulating anti-inflammatory TRIM31, demonstrating protective effects in models of LPS-induced acute lung injury in both cellular and animal studies.

Research Area

Immunology & Inflammation, Signal Transduction

Images & Validation

Key Properties

CAS Number76588-87-9
MW574.57
Purity99.98%
FormulaC26H38O14
SMILESO=C1OC2CC3C(=CC(OC4OC(CO)C(O)C(O)C4O)C(O)C3(C)C5C(O)C(O)C6(OCC25C6(O)C1O)C)C
TargetROS,NF-κB,NOD,NOD-like Receptor (NLR)

Bioactivity

In Vivo
In LPS-induced acute lung injury (ALI) mouse models, intravenous administration of Yadanzigan (5 or 10 mg/kg) significantly reduced NLRP3 and caspase-1 expression in lung tissues, alleviated histopathological damage, lowered leukocyte infiltration and inflammatory cytokines (IL-1β, TNF-α, IL-6), and improved survival.
In Vitro
Yadanzigan (20–80 μM; 24 h) significantly inhibited LPS (1 μg/mL) + ATP (5 mM)–induced NLRP3 inflammasome activation in RAW264.7, J774A.1, and THP-1 macrophages, reducing caspase-1 and IL-1β expression/secretion, enhancing TRIM31 expression, and suppressing mitochondrial ROS production.

Storage & Handling

Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

YDZG

Similar Products

  • Yadanzigan [orb3054382]

    >98% (HPLC)

    76588-87-9

    574.6

    C26H38O14

    5 mg, 100 mg, 50 mg, 25 mg
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Key Properties

No computed properties available.

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Yadanzigan (orb2944186)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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1 mg
$ 210.00
5 mg
$ 440.00
10 mg
$ 640.00
25 mg
$ 980.00
50 mg
$ 1,290.00
DispatchUsually dispatched within 5-10 working days
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