10-Hydroxycamptothecin

SKU: orb1225777

Description

(S)-10-Hydroxycamptothecin is a clinical therapy agent against hepatoma. (In Vitro):(S)-10-Hydroxycamptothecin (5-20 μg/L; 6 days; Hep G2 cells) treatment results in the cell cycle arrest at G2/M phase.(S)-10-Hydroxycamptothecin induces differentiation, down-regulates nuclear antigen (PCNA) and up-regulates wild-type protein p53 in Hep G2 cells.(S)-10-Hydroxycamptothecin inhibits L1210 leukemia cells with an IC50 of 1.15 μM.(In Vivo):(S)-10-Hydroxycamptothecin (10-Hydroxycamptothecin) against L1210 leukemia in mice is tested. At the optimal dose (15 mg/kg), (S)-10-Hydroxycamptothecin has a 71% increase in life span (ILS).

Images & Validation

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Key Properties

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CAS Number	19685-09-7
MW	364.36
Purity	>98% (HPLC)
Formula	C₂₀H₁₆N₂O₅
SMILES	O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=CC(O)=CC=C5N=C4C3=C2)=O
Target	Topoisomerase
Solubility	DMSO: 8 mg/mL warmed (21.95 mM)

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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ChEMBL 273862 | NSC 107124

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Gene Symbol

Topoisomerase

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