Angoline hydrochloride

SKU: orb1981774

Description

Angoline hydrochloride, also known as 6-Methoxyldihydrochelerythrine, is a bioactive small molecule isolated from Zanthoxylum nitidum. It functions as an inhibitor of the IL-6/STAT3 signaling pathway, demonstrating anticancer activity in vitro. This compound is a valuable research tool for studying STAT3-dependent mechanisms in oncology and inflammation.

Research Area

Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	1071676-04-4
MW	415.87
Purity	98.60%
Formula	C₂₂H₂₂ClNO₅
SMILES	Cl.O(C=1C=CC=2C3=CC=C4C=C5OCOC5=CC4=C3N(C)C(OC)C2C1OC)C
Target	IL Receptor,STAT

Bioactivity

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Target IC50

STAT3:11.56 μM

In Vitro

Angoline hydrochloride acting in the range of 0 to 100 μM for 1 hr was able to inhibit STAT3, STAT1 and NF-κB signaling pathways with the IC50 of 11.56 μM, >100 μM and >100 μM, respectively. Angoline hydrochloride acted in the range of 0 to 100 μM for 2 hours and was able to affect the phosphorylation process of STAT3. Angoline hydrochloride acting in the range of 0 to 100 μM for 72 hours was able to inhibit the proliferation of MDA-MB-231, H4 and HepG2 cells.

Storage & Handling

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Storage	keep away from direct sunlight,keep away from moisture,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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STAT3, IL Receptor, IL-6, ILReceptor, 6-Methoxyldihydrochelerythrine

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Compound Identifiers

PubChem CID

162642249 ↗

Key Properties

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No computed properties available.

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