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Angoline

SKU: orb1218462

Description

Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.

Images & Validation

Key Properties

CAS Number21080-31-9
MW379.41
Purity>98% (HPLC)
FormulaC22H21NO5
SMILESCN(C1OC)c2c(cc3OCOc3c3)c3ccc2-c(cc2)c1c(OC)c2OC
TargetIL Receptor
SolubilityIn Vitro: DMSO : 20.83 mg/mL (54.90 mM)

Bioactivity

In Vitro
Western blot analysis. Cell line: HepG2/STAT3 cell line. Concentration: 0, 1, 10, 30 and 100 μM. Incubation time: 2 hours. Result: Inhibited IL-6-induced phosphorylation of STAT3 in HepG2/STAT3 cells. Cell Proliferation Assay Cell line: MDA-MB-231, H4 and HepG2 cell lines. Concentration: 0-100 μM. Incubation time: 72 hours. Result: Inhibited proliferation of MDA-MB-231, H4 and HepG2 cells with IC50 values of 3.32, 4.72 and 3.14 μM, respectively.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

6-Methoxyldihydrochelerythrine

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Angoline (orb1218462)

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200 mg
500 mg
5 mg
$ 220.00
10 mg
$ 310.00
25 mg
$ 500.00
50 mg
$ 720.00
100 mg
$ 1,030.00