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Angoline

SKU: orb1297008

Description

Angoline hydrochloride is a potent and selective small molecule inhibitor of the IL-6/STAT3 signaling pathway (IC50: 11.56 µM). It suppresses STAT3 phosphorylation and downstream gene expression, demonstrating anti-proliferative effects in cancer cell studies, making it a valuable research tool for oncology and immunology.

Research Area

Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number21080-31-9
MW379.41
Purity99.96%
FormulaC22H21NO5
SMILESCOC1N(C)c2c(ccc3cc4OCOc4cc23)-c2ccc(OC)c(OC)c12
TargetIL Receptor,Interleukin,STAT
SolubilityDMSO:9.06 mg/mL (23.88 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.27 mM)

Bioactivity

Target IC50
IL-6/STAT3 signaling pathway:11.56 μM (IC50)
In Vitro
Angoline as a potent and selective inhibitor of the STAT3 signaling pathway (IC50=11.56 μM). Angoline inhibited STAT3 phosphorylation and its target gene expression and consequently induced growth inhibition of human cancer cells with constitutively activated STAT3 (IC50=3.14-4.72 μM). This work provided a novel lead for the development of anti-cancer agents targeting the STAT3 signaling pathway.

Storage & Handling

Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

IL Receptor, Inhibitor, ILReceptor, IL-6, inhibit, 6-Methoxyldihydrochelerythrine, Angoline, anticancer, proliferation, STAT3, STAT, phosphorylation

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Angoline (orb1297008)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 80.00
5 mg
$ 130.00
1 ml x 10 mM (in DMSO)
$ 140.00
10 mg
$ 190.00
25 mg
$ 340.00
50 mg
$ 520.00
100 mg
$ 730.00
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