Butin

SKU: orb3054128

Description

Butin, a major biologically active flavonoid isolated from the Dalbergia odorifera, has strong antioxidant, anti-inflammatory and antiplatelet activities.

Images & Validation

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Key Properties

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CAS Number	21913-99-5
MW	272.25
Purity	>98% (HPLC)
Formula	C₁₅H₁₂O₅
Solubility	DMSO : 100 mg/mL (367.30 mM; ultraphonic; )

Bioactivity

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In Vivo

Animal model: C57/BL6J mice induced by STZ. Dosage: 10, 20, 40 mg/kg; twice a day; 15 days. Administration: Oral. Result: Improved cardiac function, significant increases in LVSP, +dP/dtmax and-dP/dtmin, reduced myocardial infarction area, reduced caspase-3 activity and Bax/Bcl-2 ratio, reduced GSH-px, GSH, SOD, CAT and GR activity. Animal model: Intracerebral hemorrhage rats. Dosage: 25, 50 mg/kg; single dose. Administration: Intraperitoneal injection (i.p.). Result: Increased the neurological score, significantly reduced the volume of hemorrhagic lesions, significantly reduced the Bax/Bcl-2 ratio and caspase-3 protein expression, and significantly reduced brain tissue inflammatory mediators tumor necrosis factor-α (TNF-α) and interleukin. Reduced levels of 6 (IL-6).

In Vitro

Cell Viability Assay Cell line: H9c2. Concentration: 12.5, 25, 50 μM Incubation time: 6 h. Result: Increased cell survival in a dose-dependent manner. Western blot analysis. Cell line: H9c2. Concentration: 12.5, 25, 50 μM Incubation time: 6 h. Result: Increased the expression of GSH-px, GSH, SOD, CAT and HO-1.Real Time qPCR Cell line: H9c2. Concentration: 12.5, 25, 50 μM Incubation time: 6 h. Result: Increased the levels of Nrf2 in the cytoplasm and nucleus in a dose-dependent manner and enhanced the expressions of GSH-px, GSH, SOD, CAT and HO-1.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Butin (orb3054128)

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Purity:	99.96% (May vary between batches)
CAS Number:	492-14-8
MW:	272.25
Formula:	C₁₅H₁₂O₅

Purity:	99.91%
CAS Number:	21913-99-5
MW:	272.25
Formula:	C₁₅H₁₂O₅

CAS Number:	74628-42-5
MW:	272.25
Formula:	C₁₅H₁₂O₅

Purity:	>98% (HPLC)
CAS Number:	492-14-8
MW:	272.25
Formula:	C₁₅H₁₂O₅

Butin

Description

Images & Validation

Key Properties

Bioactivity

Storage & Handling

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Butin (orb3054128)

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