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GS-5734

SKU: orb1941066

Description

GS-5734 (Remdesivir) is a monophosphoramidate prodrug of adenosine analogue that exhibits antiviral activity against multiple variants of EBOV (EC50=70-140 nM) and other filoviruses (EC50=0.019-1.48 uM) in cell-based assays; suppresses EBOV replication and protects 100% of EBOV-infected animals against lethal disease, ameliorating clinical disease signs and pathophysiological markers.Ebola Virus Infection Phase 2 Clinical(In Vitro):Remdesivir (GS-5734) inhibits murine hepatitis virus (MHV) with an EC50 of 30 nM, and blocks SARS-CoV and MERS-CoV in HAE cells with EC50s of both 74 nM in HAE cells after treatment for 24 h.

Images & Validation

Key Properties

CAS Number1809249-37-3
MW601.597
Purity>98% (HPLC)
FormulaC28H36N5O8P
SMILESCCC(CC)COC([C@H](C)N[P@](OC[C@H]1O[C@](C2=CC=C3N2N=CC=C3N)(C#N)[C@H](O)[C@@H]1O)(OC4=CC=CC=C4)=O)=O
TargetFilovirus
SolubilityDMSO : ≥ 125 mg/mL 207.44 mM

Bioactivity

In Vitro
Remdesivir (GS-5734) inhibits murine hepatitis virus (MHV) with an EC50 of 30 nM, and blocks SARS-CoV and MERS-CoV in HAE cells with EC50s of both 74 nM in HAE cells after treatment for 24 h.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

GS 5734 | GS5734 | Remdesivir

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Protocol Information

GS-5734 (orb1941066)

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Available Sizes

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500 mg
5 mg
$ 430.00
10 mg
$ 650.00
25 mg
$ 960.00
50 mg
$ 1,330.00
100 mg
$ 1,780.00
200 mg
$ 2,340.00