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MYCi361

SKU: orb1220011

Description

MYCi361 is an inhibitor of MYC (binding to MYC with Kd of 3.2 μM). MYCi361 is a small-molecule MYC inhibitors that inhibits the viability of MYC-dependent cancer cells including prostate cancer (MycCaP, LNCaP, and PC3), leukemia (MV4-11), lymphoma (HL-60 and P493-6), and neuroblastoma (SK-N-B2) with low-micromolar IC50 values.MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy.

Images & Validation

Key Properties

CAS Number2289690-31-7
MW594.86
Purity>98% (HPLC)
FormulaC26H16ClF9N2O2
SMILESCn1nc(cc1-c1ccc(OCc2ccc(Cl)cc2)c(-c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1O)C(F)(F)F
Targetc-Myc
SolubilityDMSO:100 mg/mL (168.1 mM; Need ultrasonic)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

NUCC-0196361

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MYCi361 (orb1220011)

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Available Sizes

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200 mg
500 mg
5 mg
$ 400.00
10 mg
$ 620.00
25 mg
$ 990.00
50 mg
$ 1,380.00
100 mg
$ 1,850.00