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MYCi361

SKU: orb1309379

Description

MYCi361

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number2289690-31-7
MW594.86
Purity99.52%
FormulaC26H16ClF9N2O2
SMILESCn1nc(cc1-c1ccc(OCc2ccc(Cl)cc2)c(c1O)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(F)(F)F
Targetc-Myc
Solubility10% DMSO+90% Corn Oil:3.3 mg/mL (5.55 mM);DMSO:100 mg/mL (168.11 mM)

Bioactivity

Target IC50
MYC:3.2 μM(Kd)
In Vivo
MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy.
In Vitro
MYCi361 is a small-molecule MYC inhibitors that inhibit the viability of MYC-dependent cancer cells including prostate cancer (MycCaP, LNCaP, and PC3), leukemia (MV4-11), lymphoma (HL-60 and P493-6), and neuroblastoma (SK-N-B2) with low-micromolar IC50 value.
Animal Research
FVB or NSG Male mice of 6-8 weeks of age and 25 g bearing established MycCaP tumors.MYCi361 treatment i.p. initially at 50 mg/kg twice daily for 2 days, then 70 mg/kg/day for 9 days

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

c-Myc, cMyc, MYC, Myc, MYCi 361, MYCi361, MYCi-361, inhibit, NUCC0196361, NUCC-0196361, NUCC 0196361, Inhibitor

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Key Properties

No computed properties available.

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MYCi361 (orb1309379)

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% DMSO +
%+
% Tween 80 +
%

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1 mg
$ 160.00
5 mg
$ 330.00
10 mg
$ 500.00
25 mg
$ 800.00
50 mg
$ 1,100.00
100 mg
$ 1,470.00
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