NF-κB degrader 1

NF-κBdegrader 1 (Compound MD-1) is an NF-κB1p105 subunit degrader. It exhibits anti-inflammatory properties, with an IC50 of 2.02 μM for inhibiting TNF-α and 5.40 μM for inhibiting NO. NF-κBdegrader 1 induces p105 degradation via the Cullin-RING ligase (CRL) SCFBTCP, thereby inhibiting NF-κB transcriptional activity. This compound shows potential for research in inflammation-related diseases.