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SRI-011381

SKU: orb1223258

Description

SRI-011381 is an agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.

Images & Validation

Key Properties

CAS Number1629138-41-5
MW329.48
Purity>98% (HPLC)
FormulaC20H31N3O
SMILESO=C(NC1=NC2=CC=C(CN3CCC(C(C)(O)C)CC3)C=C2N1[C@H]4CC[C@@H](C(NC(C)C)=O)CC4)C5=CC=C(F)C=C5
TargetPARP
SolubilityIn Vitro: DMSO : 50 mg/mL (151.75 mM)

Bioactivity

In Vivo
Animal model: YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE). Dosage: 30 mg/kg. Administration: Intraperitoneally injection; every 2 d; for 22 days. Result: Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SRI-011381 | SRI 011381 | SRI011381

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Quality Guarantee

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Protocol Information

SRI-011381 (orb1223258)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 80.00
5 mg
$ 110.00
10 mg
$ 180.00
25 mg
$ 340.00
50 mg
$ 540.00
100 mg
$ 870.00
200 mg
$ 1,200.00
500 mg
$ 1,760.00