Tamoxifen

SKU: orb2281178

Description

Tamoxifen is an orally active SERM that acts as an estrogen antagonist in breast tissue and an agonist in bone and liver. It is widely used in research to create gene knockout and liver injury models in mice and has been studied for its roles in modulating autophagy, apoptosis, and viral infection pathways in vitro.

Research Area

Cell Biology, Metabolism Research, Signal Transduction

Images & Validation

−

Key Properties

−

CAS Number	10540-29-1
MW	371.51
Purity	99.92% (May vary between batches)
Formula	C₂₆H₂₉NO
SMILES	CC\C(C1=CC=CC=C1)=C(/C1=CC=CC=C1)C1=CC=C(OCCN(C)C)C=C1
Target	Autophagy,HSP,Estrogen/progestogen Receptor,Apoptosis,Estrogen Receptor/ERR
Solubility	Corn oil:40 mg/mL (107.67 mM);Ethanol:100 mg/mL (269.17 mM);DMSO:12.5 mg/mL (33.65 mM)

Bioactivity

−

Target IC50	CHO cells:> 100 μM\|A253 cells:8.92 μM\|B16 F10 cells:64.87 μM\|A549 cells:1.86 μg/mL\|Astrocytes:> 10 μM\|DLD-1 cells:11.06 μM\|FaDu cells:5.39 μM\|A2058 cells:12.5 μM (EC50)\|DU-145 cells:10.87 μM\|A431 cells:> 100 μM\|518A2 cells:7.62 μM\|A2780 cells:7.77 μM Read more...
In Vivo	METHODS: To test the antitumor activity in vivo, Tamoxifen (100 mg/kg) was administered orally to NCr athymic nude mice bearing ER-negative breast cancer tumors MDA-MB-468 or HCC-1937 three times per week for four to five weeks. RESULTS: Tamoxifen significantly inhibited the growth of MDA-MB-468 tumors, whereas the growth of HCC-1937 tumors was not affected. METHODS: To test the effect on mouse behavior, Tamoxifen (75 mg/kg in 10% ethanol+90% sunflower seed oil) was administered intraperitoneally to C57BL/6 mice once a day for seven days. RESULTS: Tamoxifen affects motor activity, socialization, and anxiety in mice. Read more...
In Vitro	METHODS: Human breast cancer cells MCF-7 were treated with Tamoxifen (0.25-4 μM) for 24 h. Cell viability was measured using the CCK-8. RESULTS: Tamoxifen significantly inhibited the proliferation of MCF-7 cells in a dose-dependent manner. METHODS: ER-negative breast cancer cells SK-BR3, MDA-MB-453, MDA-MB-468, MDA-MB-231, and HCC-1937 were treated with Tamoxifen (1-10 μM) for 24-36 h, and apoptosis was detected using Flow Cytometry. RESULTS: Tamoxifen induced apoptosis in MDA-MB-231, MDA-MB-468, MDA-MB-453 and SK-BR3 cells in a dose- and time-dependent manner, while no significant apoptotic effect was observed in HCC-1937 cells. Read more...

Storage & Handling

−

Storage	keep away from direct sunlight,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

ICI 47699, ICI46474, ICI-46474, ICI47699, ICI-47699, ERR, ER, Estrogen Receptor, EstrogenReceptor, Estrogen Receptor/ERR, Hsp90, HSP, liver, modulator, chaperone, (Z)-Tamoxifen, Apoptosis, Autophagy, ATPase, SERM, progestogenReceptor, progestogen Receptor, Tamoxifen, Z-Tamoxifen, trans-Tamoxifen, uterine

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

2733526 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

Tamoxifen (orb2281178)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

Applications:	FACS, IF, IHC-P, WB
Reactivity:	Human
Species/Host:	Mouse
Clonality:	Monoclonal
Conjugation:	Unconjugated

Applications:	FACS, IF, IHC-P, WB
Reactivity:	Human
Species/Host:	Mouse
Clonality:	Monoclonal
Conjugation:	Unconjugated

Applications:	FACS, IHC-P
Reactivity:	Human
Species/Host:	Mouse
Clonality:	Monoclonal
Conjugation:	Unconjugated

Applications:	FACS, IHC-P
Reactivity:	Human
Species/Host:	Mouse
Clonality:	Monoclonal
Conjugation:	Unconjugated

Applications:	IF, IHC-Fr, IHC-P
Predicted Reactivity:	Bovine, Canine, Equine, Human, Porcine, Rabbit, Rat, Sheep
Reactivity:	Mouse
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Tamoxifen

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

ER Antibody / Estrogen Receptor alpha [orb248339]

ER Antibody / Estrogen Receptor alpha [orb2637705]

Estrogen Receptor alpha Antibody [orb2643218]

Estrogen Receptor alpha Antibody [orb639637]

RBFOX2 Rabbit Polyclonal Antibody [orb156923]

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

Tamoxifen (orb2281178)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors