Thalidomide

SKU: orb1310829

Description

Thalidomide is a synthetic glutamic acid derivative with known teratogenic effects. It is widely used in research for its immunomodulatory, anti-inflammatory, and anti-angiogenic properties, applicable in both in vitro and in vivo studies of cancer, autoimmune diseases, and angiogenesis.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Images & Validation

−

Key Properties

−

CAS Number	50-35-1
MW	258.23
Purity	99.88% (May vary between batches)
Formula	C₁₃H₁₀N₂O₄
SMILES	O=C1N(C2CCC(=O)NC2=O)C(=O)c2ccccc12
Target	Molecular Glues,Autophagy,TNF,Ligands for E3 Ligase,Apoptosis
Solubility	DMSO:125 mg/mL (484.06 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.87 mM)

Bioactivity

−

Target IC50	CRL4CRBN:250 nM (Kd)
In Vivo	Administering 200mg/kg of Thalidomide resulted in the inhibition of vascularization in the corneal region within rabbits, with the inhibition rate ranging from 30% to 51% across three experiments. Read more...
In Vitro	Thalidomide selectively inhibits the production of tumor necrosis factor-alpha (TNF-α) in human monocytes stimulated by lipopolysaccharides and other agonists. Its suppression of TNF-α is mediated through the enhancement of mRNA degradation. Moreover, thalidomide exerts a direct effect on MM cell lines by inducing apoptosis and G1 phase growth arrest, as well as on patient MM cells resistant to melphalan, doxorubicin hydrochloride, and dexamethasone. Read more...

Storage & Handling

−

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

Sedoval, Thalomid, TNF-α, Thalidomide, Molecular Glues, MolecularGlues, Ligand for E3 Ligase, LigandforE3Ligase, Ligands for E3 Ligase, inhibit, Inhibitor, E3 ligase-recruiting Moiety, Apoptosis, Autophagy

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

5426 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

Thalidomide (orb1310829)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

Purity:	>98%
CAS Number:	2138439-12-8
MW:	360.364503860474
Formula:	C₁₇H₂₀N₄O₅

CAS Number:	1010100-22-7
MW:	287.270723104477
Formula:	C₁₄H₁₃N₃O₄

CAS Number:	3071165-50-6
MW:	444.52
Formula:	C₂₄H₃₂N₂O₆

CAS Number:	2740657-28-5
MW:	355.116
Formula:	C₁₃H₈BrFN₂O₄

CAS Number:	2446382-02-9
MW:	522.502
Formula:	C₂₄H₃₀N₂O₁₁

Thalidomide

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

Thalidomide-NH-PEG1-C2-NH2 [orb757663]

Thalidomide-5-CH2-NH2 hydrochloride [orb3033138]

Thalidomide-4-OH-C11-OH [orb3027458]

Thalidomide-4-F,5-Br [orb3028800]

Thalidomide-O-PEG4-acid [orb3028861]

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

Thalidomide (orb1310829)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors