Thalidomide

SKU: orb1310829

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Description

Thalidomide is a synthetic glutamic acid derivative with known teratogenic effects. It is widely used in research for its immunomodulatory, anti-inflammatory, and anti-angiogenic properties, applicable in both in vitro and in vivo studies of cancer, autoimmune diseases, and angiogenesis.

Research Area

Immunology & Inflammation, Protein Biochemistry

Images & Validation

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Key Properties

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CAS Number	50-35-1
MW	258.3
Purity	>98%
Formula	C₁₃H₁₀N₂O₄
SMILES	O=C1N(C2CCC(=O)NC2=O)C(=O)c2ccccc12
Target	Ubiquitin ligase
Solubility	Soluble in DMSO (up to 5 mg/ml).

Bioactivity

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Target IC50	CRL4CRBN:250 nM (Kd)
In Vivo	Administering 200mg/kg of Thalidomide resulted in the inhibition of vascularization in the corneal region within rabbits, with the inhibition rate ranging from 30% to 51% across three experiments. Read more...
In Vitro	Thalidomide selectively inhibits the production of tumor necrosis factor-alpha (TNF-α) in human monocytes stimulated by lipopolysaccharides and other agonists. Its suppression of TNF-α is mediated through the enhancement of mRNA degradation. Moreover, thalidomide exerts a direct effect on MM cell lines by inducing apoptosis and G1 phase growth arrest, as well as on patient MM cells resistant to melphalan, doxorubicin hydrochloride, and dexamethasone. Read more...

Storage & Handling

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Storage	RT
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Sedoval, Thalomid, TNF-α, Thalidomide, Molecular Glues, MolecularGlues, Ligand for E3 Ligase, LigandforE3Ligase, Ligands for E3 Ligase, inhibit, Inhibitor, E3 ligase-recruiting Moiety, Apoptosis, Autophagy

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Compound Identifiers

PubChem CID

5426 ↗

Key Properties

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No computed properties available.

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Thalidomide (orb1310829)

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MW:	259.218
Formula:	C₁₂H₉N₃O₄

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MW:	288.255
Formula:	C₁₄H₁₂N₂O₅

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MW:	1009.11
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MW:	294.31
Formula:	C₁₇H₁₄N₂O₃

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MW:	442.51
Formula:	C₂₃H₃₀N₄O₅

Thalidomide

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Thalidomide (orb1310829)

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