15-Lipoxygenase Inhibitor 1

SKU: orb1217457

Description

15-Lipoxygenase Inhibitor 1 is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM. 4-MMPB has IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 4-MMPB has potential for the research of prostate cancer.(In Vitro):4-MMPB has an IC50 of 69.6 μM for DPPH bleaching.4-MMPB exhibits cytotoxic activity on human PC-3 and HFF3 cell lines.4-MMPB (41.48 μM; 72 hours) induces apoptosis and DNA damage in PC-3 Cells.

Images & Validation

−

Key Properties

−

CAS Number	928853-86-5
MW	313.4
Purity	>98% (HPLC)
Formula	C₁₆H₁₉N₅S
SMILES	CC1=C2C(=NC(=N1)N3CCN(CC3)C)SC4=CC=CC=C4N2
Target	Others
Solubility	DMSO:8mg/mL (25.52mM)

Bioactivity

−

In Vitro

4-MMPB has an IC50 of 69.6 μM for DPPH bleaching.4-MMPB exhibits cytotoxic activity on human PC-3 and HFF3 cell lines.4-MMPB (41.48 μM; 72 hours) induces apoptosis and DNA damage in PC-3 Cells. Cell Viability Assay Cell line: DU145 cells, PC-3 cells, HFF3 cells. Concentration: 9.57 μM, 19.94 μM, 39.88 μM, 79.77 μM, 159.53 μM Incubation time: 24 hours, 48 hours, 72 hours. Result: Inhibited cells viability (IC50 = 79.76 μM; 24 h, 51.05 μM; 48 h, 41.48 μM; 72 h for PC-3 cells, IC50 = 255.25 μM; 24 h, 130.81 μM; 48 h, 98.91 μM; 72 h for HFF3 cells).

Storage & Handling

−

Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

4-MMPB

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Quick Database Links

Gene Symbol

Others

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols