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TNF-α Antagonist

SKU: orb1694013

Description

This exocyclic peptide TNF-α antagonist mimics the TNFRI binding site, blocking TNF-α and RANK signaling to inhibit osteoclast activation. It is a research tool used in vitro and in vivo to study inflammatory bone resorption in models of rheumatoid arthritis and systemic bone loss.

Research Area

Immunology & Inflammation; Pharmacology & Drug Discovery

Images & Validation

Key Properties

TargetTNF
CAS Number199999-60-5
MW1226.39
FormulaC58H71N11O15S2
SMILESCC(C)C[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Protocol Information

Protein Handling and Storage Guide
Protein Handling Guide
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TNF-α Antagonist (orb1694013)

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